Research lipid-lowering effect of plant sterols

Phytosterol is a kind of chemical constituents in plants, cell wall mainly existing in the plant cells, the study found the phytosterol beneficial to human health, for example, can prevent prostate disease. The study found, phytosterol has the effect of lowering blood cholesterol, inhibit the hyperplasia of mammary glands and modulate immunity. Research shows that, plant sterols and cholesterol and estrogen are similar in chemical structure, so that plant sterols can reduce cholesterol absorption in the intestine, effectively reduce the content of total blood cholesterol in patients with hyperlipidemia and low density lipoprotein cholesterol, and does not affect the content of high density lipoprotein cholesterol, good and reliable lipid-lowering effect on the patients with hyperlipidemia. Epidemiological survey found, plant sterol intake more meals, the risk for heart disease and other chronic diseases of the lower.
Objective: the effects of plant sterol lipids in hyperlipidemia model rats, ovariectomized rats with high lipid group's research, to explore the mechanism of.
Methods: male Wistar rats were randomly divided into normal control group (NC), high fat diet group (HF), low dose group (L), middle dose group (M), high dose group (H). Gavage respectively to in the high fat group and the dose group of soybean oil and plant sterol group, once a day for fourth weeks were measured 4W, serum, liver weight. Ovariectomized rat model with bilateral ovariectomy operation modeling, after twelfth days of ovariectomized rats were divided into model group, estrogen group (E2 group) plant sterols (L) low dose group, middle dose group (M), high dose group (H). The other 10 rats was sham operation as control. The rats were sacrificed, stripping uterus, liver weight, and determination of serum index. Clinical hyperlipidemia group will subjects according to the levels of serum lipid were randomly divided into 2 groups, the comparison of changes of serum indexes before and after feeding group test and trial group and control group after the experiment.
Results: plant sterol feeding had no significant effect on body weight of rats. Plant sterols have a modulatory role in lipid metabolism, can reduce total cholesterol and triglycerides, the regulating role of the former is stronger than that of the latter. Plant sterols have lower serum LDL-C, and MDA content in serum and the AI value is reduced effectively, enhance the value of the AAI. Plant sterols soft capsule can increase the high density lipoprotein cholesterol. In addition, plant sterols have certain antioxidant activity, can effectively reduce the formation of lipid peroxide in the liver.
Conclusion: plant sterols can reduce experimental hyperlipidemia rats blood TC, TG and liver fat, and can inhibit lipid peroxidation in the liver, plant sterols regulate the lipid metabolism, antioxidation and preventing atherosclerosis effect. Plant sterols on serum lipids may be related to the kinds of experimental models and plant sterols. Plant sterols soft capsule can significantly reduce the serum total cholesterol and triglyceride dyslipidemia crowd, increase high density lipoprotein cholesterol. Phytosterol capsules have no effect on the health of the subjects, with auxiliary lipid-lowering function.
Phytosterol has the functions of reducing blood fat and cholesterol levels in the blood, and its mechanism may be related to cholesterol absorption, metabolism.