The current domestic resources development appear stigmasterol

Basic -- step by step two development process of industrial biotechnology development still stigmasterol resources follow the development of high and new technology
Development and utilization of plant sterols, mainly including sitosterol, stigmasterol, campesterol etc natural product mixture, such as use consists of saponin from diosgenin, Hai Ke Geneen (fan sesame saponin), ladder Ke Geneen (sword hemp saponin), as well as solasodine is now used to starting materials industry production of steroid hormone drugs. China has long been the main use of diosgenin, a small part of the sea Ke Geneen (development research, Jianggan hot valley of Jinsha, sesame saponin resources research and development of natural products, 2007, 19:696~700) and ladder Ke Geneen; plant sterols, such that higher vascular plants through the main metabolic pathways, which can lead to the relevant organization cell distribution a plant sterol.
Obviously, the domestic light industry and chemical industry there are plenty of such plant caused resource development of phytosterol waste, preparatory work is essential to isolate available for microbial degradation of plant sterol substrates, performance of fermentation process selection relies on the breeding of bacteria, such as the common mycobacterial because of stigmasterol components exist the inhibition of fermentation and degradation activity, leads to an accumulation of target products decreased.
In recent years also have been reported in mycobacteria mutant breeding, can be used for industrial waste from cane sugar is rich in β - sitosterol and stigmasterol mixture, Yi was the mutant biotransformation, and can remove stigmasterol inhibition effect; sterol substrate microbial catalyzing different with different affinities, used as the final substrate, different the sterol mixture source consists of plant chemical different, there are effects on fermentation and degradation of these are the new hot spot of the current research and development work
Early since 70 time, the plant sterol microbial broken chain only made real experimental research parts of sporadic, there are few papers published; the national "eight five project" also contains the research content of fault chain of animal and plant sterol microorganisms, followed by the national level interrupt the project work, there is no development and utilization of industrial scale reports. Visible, the application research based on this aspect of domestic is relatively weak, such as the separation of breeding native species, and the early development of application of plant sterol materials supporting the processing technology is missing or not mature. Therefore, in recent years, highlight the "sterol development fever", blindly large-scale imports of sterols and tall oil, then "fluctuation indigestion" phenomenon.
The reason is that the domestic for decades, steroid medicine mainly highlights the chemical synthesis technology configuration, the chemical community in a strong position; biological community has been divided, the research work of reserve. In addition to the lack of substantive and effective communication and cooperation, the emergence of phytosterol microbial broken chain "float dry rash advance" phenomenon is not surprising.
Microbial degradation of phytosterol chain, producing useful steroidal intermediates androst -4- allyl -3, 17- two ketone (AD), androst -1, 4- -3, 17- two ketone (ADD), and research focus in recent years has been the formation of foreign -- 9 alpha hydroxy -AD, because the intermediate for the synthesis of efficient halogen (f, CL) cortical hormone more attractive, because of its chemical structure of 9 alpha hydroxy existence by chemical means, already can successfully introduce a halogen atom at position C9- in the C11 function, hydroxy beta introduction essential; it can provide to avoid -- Epoxy progesterone inefficient bottleneck the Diosgenin processing route of C11 α - hydroxylation Rhizopus fermentation steps